Cytoxan ® (cyclophosphamide for injection, USP) is a sterile white powder containing cyclophosphamide monohydrate. Cytoxan Tablets (cyclophosphamide tablets, USP) are for oral use and contain 25 mg or 50 mg cyclophosphamide (anhydrous). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Hi there. My mom was diagnosed with primary plasma cell leukemia about a month ago. After undergoing the initial 3 weeks of Velcade therapy the doctor is now having her begin a more aggressive treatment protocol which will involve high doses of cyclophosphamide (cytoxan) administered over 4 days as an inpatient in the hospital every 3 weeks. Abstract. Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder that can be treated with bone marrow transplantation, immunosuppressive therapy, and high-dose cyclophosphamide. High-dose Chemotherapy and Stem Cell Transplant for Hodgkin Lymphoma Stem cell transplants (SCTs) are sometimes used for hard-to-treat Hodgkin lymphoma , such as disease that doesn’t go away completely after chemotherapy (chemo) and/or radiation or lymphoma that comes back after treatment. Case Presentation. A 28-year-old female was initiated on high-dose cyclophosphamide for treatment of refractory neuromyelitis optica spectrum disorder—a group of demyelinating disorders affecting the optic nerve and spinal cord. Cardiotoxicity associated with high-dose cyclophosphamide therapy. Gottdiener JS, Appelbaum FR, Ferrans VJ, Deisseroth A, Ziegler J. The cardiac effects of chemotherapeutic regimens using high doses of cyclophosphamide (180 mg/kg over four days) were assessed in 32 patients with hematologic malignant neoplasms. High Dose Cyclophosphamide Physician-scientists at Johns Hopkins have developed a treatment program using high doses of the chemotherapy drug cyclophosphamide (trade name: cytoxan), without bone marrow transplantation, to “re-boot” the immune system and achieve long-lasting, complete remissions in some patients with severe aplastic anemia, multiple sclerosis, and other autoimmune disorders. Hi Sun45, I'm sorry to hear about your dad's situation. You may wish to read through this article regarding high-dose Cytoxan salvage therapy. The article frankly discusses the outcomes and some of the side effects (fever, neutropenia, etc) of a small cohort of patients that underwent this salvage therapy. Medscape - Indication-specific dosing for Cytoxan (cyclophosphamide), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.